An HIV-1 Env-antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes

Elicitation of broadly neutralizing antibody (bNAb) responses to the conserved elements of the HIV-1 envelope glycoproteins (Env), including the primary receptor CD4 binding site (CD4bs), is a major focus of vaccine development yet to be accomplished. However, a large number of CD4bs-directed bNAbs...

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Veröffentlicht in:J Immunol
Hauptverfasser: Chen, Yajing, Wilson, Richard, O’Dell, Sijy, Guenaga, Javier, Feng, Yu, Tran, Karen, Chiang, Chi-I, Arendt, Heather E., DeStefano, Joanne, Mascola, John R., Wyatt, Richard T., Li, Yuxing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117957/
https://ncbi.nlm.nih.gov/pubmed/27815444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601134
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