Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage

ATM (ataxia-telangiectasia mutated) is a central molecule for DNA quality control. Its activation by DNA damage promotes cell-cycle delay, which facilitates DNA repair prior to replication. On the other hand, persistent DNA damage has been implicated in ATM-dependent cell death via apoptosis; howeve...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Fletcher, Sally C, Grou, Claudia P, Legrand, Arnaud J, Chen, Xin, Soderstrom, Kalle, Poletto, Mattia, Dianov, Grigory L
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2018
Предметы:
Genome Integrity, Repair and Replication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829641/
https://ncbi.nlm.nih.gov/pubmed/29294106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1291
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы