Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells

Ataxia telangiectasia (A-T) is a syndrome associated with loss of ATM protein function. Neurodegeneration and cancer predisposition, both hallmarks of A-T, are likely to emerge as a consequence of the persistent oxidative stress and DNA damage observed in this disease. Surprisingly however, despite...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Poletto, Mattia, Yang, Di, Fletcher, Sally C., Vendrell, Iolanda, Fischer, Roman, Legrand, Arnaud J., Dianov, Grigory L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622344/
https://ncbi.nlm.nih.gov/pubmed/28973444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx635
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