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Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage
ATM (ataxia-telangiectasia mutated) is a central molecule for DNA quality control. Its activation by DNA damage promotes cell-cycle delay, which facilitates DNA repair prior to replication. On the other hand, persistent DNA damage has been implicated in ATM-dependent cell death via apoptosis; howeve...
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| 發表在: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5829641/ https://ncbi.nlm.nih.gov/pubmed/29294106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1291 |
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