Sp1 phosphorylation by ATM downregulates BER and promotes cell elimination in response to persistent DNA damage

ATM (ataxia-telangiectasia mutated) is a central molecule for DNA quality control. Its activation by DNA damage promotes cell-cycle delay, which facilitates DNA repair prior to replication. On the other hand, persistent DNA damage has been implicated in ATM-dependent cell death via apoptosis; howeve...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Fletcher, Sally C, Grou, Claudia P, Legrand, Arnaud J, Chen, Xin, Soderstrom, Kalle, Poletto, Mattia, Dianov, Grigory L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5829641/
https://ncbi.nlm.nih.gov/pubmed/29294106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1291
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