Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

BACKGROUND AND PURPOSE: Statins are amongst the most widely prescribed drugs for those at risk of cardiovascular disease, lowering cholesterol levels by inhibiting 3‐hydroxy‐3‐methylglutaryl (HMG)‐CoA reductase. Although effective at preventing cardiovascular disease, statin use is associated with m...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Venturi, Elisa, Lindsay, Chris, Lotteau, Sabine, Yang, Zhaokang, Steer, Emma, Witschas, Katja, Wilson, Abigail D, Wickens, James R, Russell, Angela J, Steele, Derek, Calaghan, Sarah, Sitsapesan, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825303/
https://ncbi.nlm.nih.gov/pubmed/29278865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14136
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