Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour

ATP is an essential constitutive regulator of cardiac ryanodine receptors (RyR2), enabling small changes in cytosolic Ca(2+) to trigger large changes in channel activity. With recent landmark determinations of the full structures of RyR1 (skeletal isoform) and RyR2 using cryo-EM, and identification...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lindsay, Chris, Sitsapesan, Mano, Chan, Wei Mun, Venturi, Elisa, Welch, William, Musgaard, Maria, Sitsapesan, Rebecca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177429/
https://ncbi.nlm.nih.gov/pubmed/30301919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33328-8
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