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Structural basis for gating and activation of RyR1
The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca(2+)) release channel required for skeletal muscle contraction. Here we present cryo-EM reconstructions of RyR1 in multiple functional states revealing the structural basis of channel gating and ligand-dependent activation. Binding...
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| Publicado no: | Cell |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5142848/ https://ncbi.nlm.nih.gov/pubmed/27662087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.075 |
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