Structural basis for gating and activation of RyR1

The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca(2+)) release channel required for skeletal muscle contraction. Here we present cryo-EM reconstructions of RyR1 in multiple functional states revealing the structural basis of channel gating and ligand-dependent activation. Binding...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell
Main Authors: des Georges, Amédée, Clarke, Oliver B., Zalk, Ran, Yuan, Qi, Condon, Kendall J., Grassucci, Robert A., Hendrickson, Wayne A., Marks, Andrew R., Frank, Joachim
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142848/
https://ncbi.nlm.nih.gov/pubmed/27662087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.075
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki