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Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour
ATP is an essential constitutive regulator of cardiac ryanodine receptors (RyR2), enabling small changes in cytosolic Ca(2+) to trigger large changes in channel activity. With recent landmark determinations of the full structures of RyR1 (skeletal isoform) and RyR2 using cryo-EM, and identification...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6177429/ https://ncbi.nlm.nih.gov/pubmed/30301919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33328-8 |
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