Regulation of effector Tregs in murine lupus

OBJECTIVE: Tregs need to acquire an effector phenotype to function in inflammatory settings. Whether effector Tregs can limit disease severity in lupus is unknown. IRF4 is an essential controller of effector Tregs and regulates their ability to express IL-10. In non-Tregs, IRF4 activity is modulated...

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Bibliografske podrobnosti
izdano v:Arthritis Rheumatol
Main Authors: Chandrasekaran, Uma, Yi, Woelsung, Gupta, Sanjay, Weng, Chien-Huan, Giannopoulou, Eugenia, Chinenov, Yurii, Jessberger, Rolf, Weaver, Casey T., Bhagat, Govind, Pernis, Alessandra B.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5825185/
https://ncbi.nlm.nih.gov/pubmed/26816213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39599
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