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The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity
Post-transcriptional modifications can control protein abundance, but the extent to which these alterations contribute to the expression of T helper (T(H)) lineage-defining factors is unknown. Tight regulation of Bcl6 expression, an essential transcription factor for T follicular helper (T(FH)) cell...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5557982/ https://ncbi.nlm.nih.gov/pubmed/28811467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00348-3 |
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