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Use of Bayesian Decision Analysis to Minimize Harm in Patient-Centered Randomized Clinical Trials in Oncology

IMPORTANCE: Randomized clinical trials (RCTs) currently apply the same statistical threshold of alpha = 2.5% for controlling for false-positive results or type 1 error, regardless of the burden of disease or patient preferences. Is there an objective and systematic framework for designing RCTs that...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Montazerhodjat, Vahid, Chaudhuri, Shomesh E., Sargent, Daniel J., Lo, Andrew W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5824294/
https://ncbi.nlm.nih.gov/pubmed/28418507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2017.0123
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