Evolution of the Randomized Clinical Trial in the Era of Precision Oncology

IMPORTANCE: The randomized clinical trial (RCT) in oncology has evolved since its widespread adoption in the 1970s. In recent years, concerns have emerged regarding the use of putative surrogate end points, such as progression-free survival (PFS), and marginal effect sizes. OBJECTIVE: To describe co...

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Bibliografiske detaljer
Udgivet i:JAMA Oncol
Main Authors: Del Paggio, Joseph C., Berry, John S., Hopman, Wilma M., Eisenhauer, Elizabeth A., Prasad, Vinay, Gyawali, Bishal, Booth, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: American Medical Association 2021
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Original Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7995135/
https://ncbi.nlm.nih.gov/pubmed/33764385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2021.0379
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