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TRPV4 channel-dependent negative feedback mechanism regulates G(q) protein-coupled receptor-induced vasoconstriction

OBJECTIVE: Several physiological stimuli activate smooth muscle cell (SMC) G(q) protein-coupled receptors (G(q)PCRs) to cause vasoconstriction. As a protective mechanism against excessive vasoconstriction, SMC G(q)PCR stimulation invokes endothelial cell (EC) vasodilatory signalling. Whether Ca(2+)...

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Publicat a:Arterioscler Thromb Vasc Biol
Autors principals: Hong, Kwangseok, Cope, Eric L., DeLalio, Leon J., Marziano, Corina, Isakson, Brant E., Sonkusare, Swapnil K.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5823749/
https://ncbi.nlm.nih.gov/pubmed/29301784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310038
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