Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers

The airway epithelium restricts the penetration of inhaled pathogens into the underlying tissue and plays a crucial role in the innate immune defense against respiratory infections. The whooping cough agent, Bordetella pertussis, adheres to ciliated cells of the human airway epithelium and subverts...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Hasan, Shakir, Kulkarni, Nikhil Nitin, Asbjarnarson, Arni, Linhartova, Irena, Osicka, Radim, Sebo, Peter, Gudmundsson, Gudmundur H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820963/
https://ncbi.nlm.nih.gov/pubmed/29203545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00445-17
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