Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis

The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) of Bordetella pertussis targets phagocytic cells expressing the complement receptor 3 (CR3, Mac-1, α(M)β(2) integrin, or CD11b/CD18). CyaA delivers into cells an N-terminal adenylyl cyclase (AC) enzyme domain that is activated by cytosolic...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Skopova, Karolina, Tomalova, Barbora, Kanchev, Ivan, Rossmann, Pavel, Svedova, Martina, Adkins, Irena, Bibova, Ilona, Tomala, Jakub, Masin, Jiri, Guiso, Nicole, Osicka, Radim, Sedlacek, Radislav, Kovar, Marek, Sebo, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442630/
https://ncbi.nlm.nih.gov/pubmed/28396322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00937-16
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