Pore-Forming and Enzymatic Activities of Bordetella pertussis Adenylate Cyclase Toxin Synergize in Promoting Lysis of Monocytes

Bordetella adenylate cyclase (AC) toxin-hemolysin (CyaA) targets myeloid phagocytes expressing the α(M)β(2) integrin (CD11b/CD18) and delivers into their cytosol an AC enzyme that converts ATP into cyclic AMP (cAMP). In parallel, CyaA acts as a hemolysin, forming small membrane pores. Using specific...

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Autori principali: Basler, Marek, Masin, Jiri, Osicka, Radim, Sebo, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Molecular Pathogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1418931/
https://ncbi.nlm.nih.gov/pubmed/16552051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.74.4.2207-2214.2006
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