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Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme
The adenylate cyclase toxin-hemolysin (CyaA, ACT or AC-Hly) is a key virulence factor of the whooping cough agent Bordetella pertussis. CyaA targets myeloid phagocytes expressing the complement receptor 3 (CR3, known as α(M)β(2) integrin CD11b/CD18 or Mac-1) and translocates by a poorly understood m...
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| Veröffentlicht in: | Pathog Dis |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4626595/ https://ncbi.nlm.nih.gov/pubmed/26391732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femspd/ftv075 |
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