Structure–Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes

Bordetellae, pathogenic to mammals, produce an immunomodulatory adenylate cyclase toxin–hemolysin (CyaA, ACT or AC-Hly) that enables them to overcome the innate immune defense of the host. CyaA subverts host phagocytic cells by an orchestrated action of its functional domains, where an extremely cat...

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Bibliographic Details
Published in:Toxins (Basel)
Main Authors: Novak, Jakub, Cerny, Ondrej, Osickova, Adriana, Linhartova, Irena, Masin, Jiri, Bumba, Ladislav, Sebo, Peter, Osicka, Radim
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5666347/
https://ncbi.nlm.nih.gov/pubmed/28946636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins9100300
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