Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs

Upon glucose restriction, eukaryotic cells upregulate oxidative metabolism to maintain homeostasis. Using genetic screens, we find that the mitochondrial serine hydroxymethyltransferase (SHMT2) is required for robust mitochondrial oxygen consumption and low glucose proliferation. SHMT2 catalyzes the...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mol Cell
Hlavní autoři: Minton, Denise R., Nam, Minwoo, McLaughlin, Daniel J., Shin, Jong, Bayraktar, Erol C., Alvarez, Samantha W., Sviderskiy, Vladislav O., Papagiannakopoulos, Thales, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819360/
https://ncbi.nlm.nih.gov/pubmed/29452640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.024
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky