Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs

Upon glucose restriction, eukaryotic cells upregulate oxidative metabolism to maintain homeostasis. Using genetic screens, we find that the mitochondrial serine hydroxymethyltransferase (SHMT2) is required for robust mitochondrial oxygen consumption and low glucose proliferation. SHMT2 catalyzes the...

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Publicado en:Mol Cell
Autores principales: Minton, Denise R., Nam, Minwoo, McLaughlin, Daniel J., Shin, Jong, Bayraktar, Erol C., Alvarez, Samantha W., Sviderskiy, Vladislav O., Papagiannakopoulos, Thales, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819360/
https://ncbi.nlm.nih.gov/pubmed/29452640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.024
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