Serine Catabolism by SHMT2 is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl tRNAs

Upon glucose restriction, eukaryotic cells upregulate oxidative metabolism to maintain homeostasis. Using genetic screens, we find that the mitochondrial serine hydroxymethyltransferase (SHMT2) is required for robust mitochondrial oxygen consumption and low glucose proliferation. SHMT2 catalyzes the...

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Udgivet i:Mol Cell
Main Authors: Minton, Denise R., Nam, Minwoo, McLaughlin, Daniel J., Shin, Jong, Bayraktar, Erol C., Alvarez, Samantha W., Sviderskiy, Vladislav O., Papagiannakopoulos, Thales, Sabatini, David M., Birsoy, Kıvanç, Possemato, Richard
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819360/
https://ncbi.nlm.nih.gov/pubmed/29452640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.024
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