Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR–Cas9 and ssODN in human cancer cells

BACKGROUND: Precise genome editing is essential for both basic and translational research. The recently developed CRISPR/Cas9 system can specifically cleave a designated site of target gene to create a DNA double-strand break, which triggers cellular DNA repair mechanism of either inaccurate non-hom...

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Detalhes bibliográficos
Publicado no:Cell Biosci
Main Authors: Hu, Zheng, Shi, Zhaoying, Guo, Xiaogang, Jiang, Baishan, Wang, Guo, Luo, Dixian, Chen, Yonglong, Zhu, Yuan-Shan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819182/
https://ncbi.nlm.nih.gov/pubmed/29468011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-018-0200-z
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