Ligase IV inhibitor SCR7 enhances gene editing directed by CRISPR–Cas9 and ssODN in human cancer cells

BACKGROUND: Precise genome editing is essential for both basic and translational research. The recently developed CRISPR/Cas9 system can specifically cleave a designated site of target gene to create a DNA double-strand break, which triggers cellular DNA repair mechanism of either inaccurate non-hom...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Biosci
Päätekijät: Hu, Zheng, Shi, Zhaoying, Guo, Xiaogang, Jiang, Baishan, Wang, Guo, Luo, Dixian, Chen, Yonglong, Zhu, Yuan-Shan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2018
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819182/
https://ncbi.nlm.nih.gov/pubmed/29468011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-018-0200-z
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