TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis

Signaling by the transforming growth factor–β (TGF-β) receptors I and II (TβRI/II) and the primary cilia-localized sonic hedgehog (Shh) pathway promote cell migration and, consequently, tumor metastasis. In contrast, the sphingolipid ceramide inhibits cell proliferation and tumor metastasis. We inve...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Gencer, Salih, Oleinik, Natalia, Kim, Jisun, Selvam, Shanmugam Panneer, De Palma, Ryan, Dany, Mohammed, Nganga, Rose, Thomas, Raquela J., Senkal, Can E., Howe, Philip H., Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818989/
https://ncbi.nlm.nih.gov/pubmed/29066540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aam7464
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