Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis

Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pH(e)) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H(+) ions reducing the intracellular pH (pH(i)). Nevertheless, how extracellular...

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Detalles Bibliográficos
Publicado en:Front Med (Lausanne)
Main Authors: Khan, Meraj A., Philip, Lijy M., Cheung, Guillaume, Vadakepeedika, Shawn, Grasemann, Hartmut, Sweezey, Neil, Palaniyar, Nades
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Medicine
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816902/
https://ncbi.nlm.nih.gov/pubmed/29487850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2018.00019
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