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Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis
Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pH(e)) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generate large amounts of H(+) ions reducing the intracellular pH (pH(i)). Nevertheless, how extracellular...
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| Publicado no: | Front Med (Lausanne) |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5816902/ https://ncbi.nlm.nih.gov/pubmed/29487850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2018.00019 |
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