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The TIA1 RNA-binding-protein family regulates EIF2AK2-mediated stress response and cell cycle progression

TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins bind target sites with identical specificity in 3′ UTRs and introns proximal to 5′ as well as 3′ splice sites. Double knockout (D...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Meyer, Cindy, Garzia, Aitor, Mazzola, Michael, Gerstberger, Stefanie, Molina, Henrik, Tuschl, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5816707/
https://ncbi.nlm.nih.gov/pubmed/29429924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.01.011
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