TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells

Cellular responses to the loss of genomic stability are well-established, while how mammalian cells respond to chromatin destabilization is largely unknown. We previously found that DNA demethylation on p53-deficient background leads to transcription of repetitive heterochromatin elements, followed...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Leonova, Katerina, Safina, Alfiya, Nesher, Elimelech, Sandlesh, Poorva, Pratt, Rachel, Burkhart, Catherine, Lipchick, Brittany, Gitlin, Ilya, Frangou, Costakis, Koman, Igor, Wang, Jianmin, Kirsanov, Kirill, Yakubovskaya, Marianna G, Gudkov, Andrei V, Gurova, Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815852/
https://ncbi.nlm.nih.gov/pubmed/29400649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30842
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