FACT is a sensor of DNA torsional stress in eukaryotic cells

Transitions of B-DNA to alternative DNA structures (ADS) can be triggered by negative torsional strain, which occurs during replication and transcription, and may lead to genomic instability. However, how ADS are recognized in cells is unclear. We found that the binding of candidate anticancer drug,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Safina, Alfiya, Cheney, Peter, Pal, Mahadeb, Brodsky, Leonid, Ivanov, Alexander, Kirsanov, Kirill, Lesovaya, Ekaterina, Naberezhnov, Denis, Nesher, Elimelech, Koman, Igor, Wang, Dan, Wang, Jianming, Yakubovskaya, Marianna, Winkler, Duane, Gurova, Katerina
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2017
Gaiak:
Molecular Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389579/
https://ncbi.nlm.nih.gov/pubmed/28082391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1366
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