Ca(2+)-dependent regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis

In inflammatory arthritis, the dysregulation of osteoclast activity by pro-inflammatory cytokines, including TNF, interferes with bone remodeling during inflammation through Ca(2+)-dependent mechanisms causing pathological bone loss. Ca(2+)-dependent CREB/c-fos activation via CaMKIV induces transcri...

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Bibliographic Details
Published in:J Immunol
Main Authors: Grössinger, Eva M., Kang, Mincheol, Bouchareychas, Laura, Sarin, Ritu, Haudenschild, Dominik R., Borodinsky, Laura N., Adamopoulos, Iannis E.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815326/
https://ncbi.nlm.nih.gov/pubmed/29246953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1701170
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