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Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
Genome editing with the CRISPR–Cas9 system has enabled unprecedented efficacy for reverse genetics and gene correction approaches. While off-target effects have been successfully tackled, the effort to eliminate variability in sgRNA efficacies—which affect experimental sensitivity—is in its infancy....
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| Publié dans: | Nucleic Acids Res |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5814880/ https://ncbi.nlm.nih.gov/pubmed/29267886 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1268 |
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