CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo

Chromosomal translocations that generate oncogenic fusion proteins are causative for most pediatric leukemias and frequently affect the MLL/KMT2A gene. In vivo modeling of bona fide chromosomal translocations in human hematopoietic stem and progenitor cells is challenging but essential to determine...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Reimer, Jana, Knöß, Sabine, Labuhn, Maurice, Charpentier, Emmanuelle M., Göhring, Gudrun, Schlegelberger, Brigitte, Klusmann, Jan-Henning, Heckl, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685230/
https://ncbi.nlm.nih.gov/pubmed/28572162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.164046
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