Peptidic inhibitors of insulin-degrading enzyme with potential for dermatological applications discovered via phage display

Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing. Pharmacological inhibitors of IDE administered internally have been shown to slow the breakdow...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Suire, Caitlin N., Nainar, Sarah, Fazio, Michael, Kreutzer, Adam G., Paymozd-Yazdi, Tara, Topper, Caitlyn L., Thompson, Caroline R., Leissring, Malcolm A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814047/
https://ncbi.nlm.nih.gov/pubmed/29447281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193101
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