Targeting Insulin-Degrading Enzyme in Insulin Clearance

Hepatic insulin clearance, a physiological process that in response to nutritional cues clears ~50–80% of circulating insulin, is emerging as an important factor in our understanding of the pathogenesis of type 2 diabetes mellitus (T2DM). Insulin-degrading enzyme (IDE) is a highly conserved Zn(2+)-m...

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Bibliografische gegevens
Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Leissring, Malcolm A., González-Casimiro, Carlos M., Merino, Beatriz, Suire, Caitlin N., Perdomo, Germán
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Review
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956289/
https://ncbi.nlm.nih.gov/pubmed/33668109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22052235
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