Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resista...

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Pubblicato in:Metabolism
Autori principali: Villa-Pérez, Pablo, Merino, Beatriz, Fernández-Díaz, Cristina M., Cidad, Pilar, Lobatón, Carmen D., Moreno, Alfredo, Muturi, Harrison T., Ghadieh, Hilda E., Najjar, Sonia M., Leissring, Malcolm A., Cózar-Castellano, Irene, Perdomo, Germán
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185772/
https://ncbi.nlm.nih.gov/pubmed/30098324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2018.08.001
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