Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation

Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn’s disease (CD) patients is correlated with loss of tolerance against the host gut flora. Gp96 has been stablished to be an essential chaperone for Toll-like receptors (TLRs). We st...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cosin-Roger, Jesus, Spalinger, Marianne R., Ruiz, Pedro A., Stanzel, Claudia, Terhalle, Anne, Wolfram, Lutz, Melhem, Hassan, Atrott, Kirstin, Lang, Silvia, Frey-Wagner, Isabelle, Fried, Michael, Scharl, Michael, Hausmann, Martin, Rogler, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814018/
https://ncbi.nlm.nih.gov/pubmed/29447283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193003
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