Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation

Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn’s disease (CD) patients is correlated with loss of tolerance against the host gut flora. Gp96 has been stablished to be an essential chaperone for Toll-like receptors (TLRs). We st...

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Pubblicato in:PLoS One
Autori principali: Cosin-Roger, Jesus, Spalinger, Marianne R., Ruiz, Pedro A., Stanzel, Claudia, Terhalle, Anne, Wolfram, Lutz, Melhem, Hassan, Atrott, Kirstin, Lang, Silvia, Frey-Wagner, Isabelle, Fried, Michael, Scharl, Michael, Hausmann, Martin, Rogler, Gerhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814018/
https://ncbi.nlm.nih.gov/pubmed/29447283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193003
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