Activation of Protein Tyrosine Phosphatase Non-Receptor Type 2 by Spermidine Exerts Anti-Inflammatory Effects in Human THP-1 Monocytes and in a Mouse Model of Acute Colitis

BACKGROUND: Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2). As PTPN2 is known to be a negative regulator of interferon-gamma (IFN-γ)-induced responses, and IFN-γ stimulation of immune cells is a critical process in the immunopathol...

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Main Authors: Morón, Belén, Spalinger, Marianne, Kasper, Stephanie, Atrott, Kirstin, Frey-Wagner, Isabelle, Fried, Michael, McCole, Declan F., Rogler, Gerhard, Scharl, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767590/
https://ncbi.nlm.nih.gov/pubmed/24040033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073703
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