Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion

The Crohn's disease candidate gene, protein tyrosine phosphatase nonreceptor type 2 (PTPN2), has been shown to regulate epidermal growth factor (EGF)-induced phosphatidylinositol 3-kinase (PI3K) activation in fibroblasts. In intestinal epithelial cells (IECs), EGF-induced EGF receptor (EGFR) ac...

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Detalhes bibliográficos
Principais autores: Scharl, Michael, Rudenko, Ivan, McCole, Declan F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Mucosal Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957338/
https://ncbi.nlm.nih.gov/pubmed/20689057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00106.2010
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