Protein Tyrosine Phosphatase Non-Receptor Type 22 Modulates NOD2-Induced Cytokine Release and Autophagy

BACKGROUND: Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD). PTPN22 is involved in the regulation of T- and B-cell receptor signaling, but although it is highly expressed in...

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Detalhes bibliográficos
Main Authors: Spalinger, Marianne R., Lang, Silvia, Vavricka, Stephan R., Fried, Michael, Rogler, Gerhard, Scharl, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753240/
https://ncbi.nlm.nih.gov/pubmed/23991106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072384
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