Allele-specific chromatin recruitment and therapeutic vulnerabilities of ESR1 activating mutations

Estrogen receptor α (ER) ligand-binding domain (LBD) mutations are found in a substantial number of endocrine treatment-resistant metastatic ER-positive (ER(+)) breast cancers. We investigated the chromatin recruitment, transcriptional network and genetic vulnerabilities in breast cancer models harb...

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Publicat a:Cancer Cell
Autors principals: Jeselsohn, Rinath, Bergholz, Johann S, Pun, Matthew, Cornwell, MacIntosh, Liu, Weihan, Nardone, Agostina, Xiao, Tengfei, Li, Wei, Qiu, Xintao, Buchwalter, Gilles, Feiglin, Ariel, Abell-Hart, Kayley, Fei, Teng, Rao, Prakash, Long, Henry, Kwiatkowski, Nicholas, Zhang, Tinghu, Gray, Nathanael, Melchers, Diane, Houtman, Rene, Liu, X. Shirley, Cohen, Ofir, Wagle, Nikhil, Winer, Eric P., Zhao, Jean, Brown, Myles
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813700/
https://ncbi.nlm.nih.gov/pubmed/29438694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.01.004
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