ESR1 mutations as a mechanism for acquired endocrine resistance in breast cancer

Most breast cancers are estrogen receptor α (ER)-positive (+) and are treated with endocrine therapies targeting ER activity. Despite efforts, the mechanisms of the frequent clinical resistance to these therapies remain largely unknown. Several recent parallel studies unveiled gain-of-function recur...

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Udgivet i:Nat Rev Clin Oncol
Main Authors: Jeselsohn, Rinath, Buchwalter, Gilles, De Angelis, Carmine, Brown, Myles, Schiff, Rachel
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911210/
https://ncbi.nlm.nih.gov/pubmed/26122181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2015.117
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