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ESR1 mutations as a mechanism for acquired endocrine resistance in breast cancer
Most breast cancers are estrogen receptor α (ER)-positive (+) and are treated with endocrine therapies targeting ER activity. Despite efforts, the mechanisms of the frequent clinical resistance to these therapies remain largely unknown. Several recent parallel studies unveiled gain-of-function recur...
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| Published in: | Nat Rev Clin Oncol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4911210/ https://ncbi.nlm.nih.gov/pubmed/26122181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrclinonc.2015.117 |
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