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Is ctDNA the roadmap to the landscape of the clonal mutational evolution in drug resistance? Lessons from the PALOMA-3 Study, and implications for precision medicine
The correlative ctDNA studies of the PALOMA-3 clinical trial showed that acquired resistance to fulvestrant and palbociclib are associated with clonal evolution and acquired mutations in RB1, PIK3CA, and ESR1, with the latter two related to fulvestrant resistance. These results highlight the potenti...
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| Publicado en: | Cancer Discov |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217858/ https://ncbi.nlm.nih.gov/pubmed/30385523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1084 |
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