Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses

Histone deacetylase inhibitors (HDACi) modulate the transcriptional activity of all cells, including innate and adaptive immune cells. Therefore, we aimed to evaluate immunological effects of treatment with the HDACi panobinostat in HIV-infected patients during a clinical phase IIa latency reversal...

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Vydáno v:mSphere
Hlavní autoři: Brinkmann, Christel Rothe, Højen, Jesper Falkesgaard, Rasmussen, Thomas Aagaard, Kjær, Anne Sofie, Olesen, Rikke, Denton, Paul W., Østergaard, Lars, Ouyang, Zhengyu, Lichterfeld, Mathias, Yu, Xu, Søgaard, Ole Schmeltz, Dinarello, Charles, Tolstrup, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812898/
https://ncbi.nlm.nih.gov/pubmed/29468194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00616-17
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