Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses

Histone deacetylase inhibitors (HDACi) modulate the transcriptional activity of all cells, including innate and adaptive immune cells. Therefore, we aimed to evaluate immunological effects of treatment with the HDACi panobinostat in HIV-infected patients during a clinical phase IIa latency reversal...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:mSphere
Päätekijät: Brinkmann, Christel Rothe, Højen, Jesper Falkesgaard, Rasmussen, Thomas Aagaard, Kjær, Anne Sofie, Olesen, Rikke, Denton, Paul W., Østergaard, Lars, Ouyang, Zhengyu, Lichterfeld, Mathias, Yu, Xu, Søgaard, Ole Schmeltz, Dinarello, Charles, Tolstrup, Martin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5812898/
https://ncbi.nlm.nih.gov/pubmed/29468194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00616-17
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