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Impaired cohesion and homologous recombination during replicative aging in budding yeast

The causal relationship between genomic instability and replicative aging is unclear. We reveal here that genomic instability at the budding yeast ribosomal DNA (rDNA) locus increases during aging, potentially due to the reduced cohesion that we uncovered during aging caused by the reduced abundance...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Pal, Sangita, Postnikoff, Spike D., Chavez, Myrriah, Tyler, Jessica K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5810620/
https://ncbi.nlm.nih.gov/pubmed/29441364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaq0236
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