Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

All eukaryotic cells divide a finite number of times, although the mechanistic basis of this replicative aging remains unclear. Replicative aging is accompanied by a reduction in histone protein levels, and this is a cause of aging in budding yeast. Here we show that nucleosome occupancy decreased b...

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Main Authors: Hu, Zheng, Chen, Kaifu, Xia, Zheng, Chavez, Myrriah, Pal, Sangita, Seol, Ja-Hwan, Chen, Chin-Chuan, Li, Wei, Tyler, Jessica K.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937517/
https://ncbi.nlm.nih.gov/pubmed/24532716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.233221.113
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