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Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging
All eukaryotic cells divide a finite number of times, although the mechanistic basis of this replicative aging remains unclear. Replicative aging is accompanied by a reduction in histone protein levels, and this is a cause of aging in budding yeast. Here we show that nucleosome occupancy decreased b...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937517/ https://ncbi.nlm.nih.gov/pubmed/24532716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.233221.113 |
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