A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques

Trimeric HIV-1 envelope (Env) immunogens are attractive due to their ability to display quaternary epitopes targeted by broadly neutralizing antibodies (bNAbs) while obscuring unfavorable epitopes. Results from the RV144 trial highlighted the importance of vaccine-induced HIV-1 Env V1V2-directed ant...

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Vydáno v:J Virol
Hlavní autoři: Jones, Andrew T., Chamcha, Venkateswarlu, Kesavardhana, Sannula, Shen, Xiaoying, Beaumont, David, Das, Raksha, Wyatt, Linda S., LaBranche, Celia C., Stanfield-Oakley, Sherry, Ferrari, Guido, Montefiori, David C., Moss, Bernard, Tomaras, Georgia D., Varadarajan, Raghavan, Amara, Rama Rao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5809733/
https://ncbi.nlm.nih.gov/pubmed/29237847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01796-17
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